Cholesky Decomposition

Transcriptomic data clustering refers to the process of grouping similar gene expression profiles from high-throughput sequencing or microarray experiments. This technique enables researchers to identify distinct biological states or conditions by examining how genes are co-expressed across different samples. Clustering algorithms, such as hierarchical clustering, k-means, or DBSCAN, are often employed to organize the data into meaningful clusters, allowing for the discovery of gene modules or pathways that are functionally related.

The underlying principle involves measuring the similarity between expression levels, typically represented in a matrix format where rows correspond to genes and columns correspond to samples. For each gene $g_i$ and sample $s_j$, the expression level can be denoted as $E(g_i, s_j)$. By applying distance metrics (like Euclidean or cosine distance) on this data matrix, researchers can cluster genes or samples based on expression patterns, leading to insights into biological processes and disease mechanisms.

Pigou’s Wealth Effect refers to the concept that changes in the real value of wealth can influence consumer spending and, consequently, the overall economy. When the value of assets, such as real estate or stocks, increases due to inflation or economic growth, individuals perceive themselves as wealthier. This perception can lead to increased consumer confidence, prompting them to spend more on goods and services. The relationship can be mathematically represented as:

where $C$ is consumer spending and $W$ is perceived wealth. Conversely, if asset values decline, consumers may feel less wealthy and reduce their spending, which can negatively impact economic growth. This effect highlights the importance of wealth perceptions in economic behavior and policy-making.

The Bohr magneton ($\mu_B$) is a physical constant that represents the magnetic moment of an electron due to its orbital or spin angular momentum. It is defined as:

where:

• $e$ is the elementary charge,
• $\hbar$ is the reduced Planck's constant, and
• $m_e$ is the mass of the electron.

The Bohr magneton serves as a fundamental unit of magnetic moment in atomic physics and is especially significant in the study of atomic and molecular magnetic properties. It is approximately equal to $9.274 \times 10^{-24} \, \text{J/T}$. This constant plays a critical role in understanding phenomena such as electron spin and the behavior of materials in magnetic fields, impacting fields like quantum mechanics and solid-state physics.

The Lucas Critique, proposed by economist Robert Lucas in 1976, challenges the validity of traditional macroeconomic models that rely on historical relationships to predict the effects of policy changes. According to this critique, when policymakers change economic policies, the expectations of economic agents (consumers, firms) will also change, rendering past data unreliable for forecasting future outcomes. This is based on the principle of rational expectations, which posits that agents use all available information, including knowledge of policy changes, to form their expectations. Therefore, a model that does not account for these changing expectations can lead to misleading conclusions about the effectiveness of policies. In essence, the critique emphasizes that policy evaluations must consider how rational agents will adapt their behavior in response to new policies, fundamentally altering the economy's dynamics.

Farkas Lemma is a fundamental result in linear inequalities and convex analysis, providing a criterion for the solvability of systems of linear inequalities. It states that for a given matrix $A$ and vector $b$, at least one of the following statements is true:

1. There exists a vector $x$ such that $Ax \leq b$.
2. There exists a vector $y$ such that $A^T y = 0$ and $y \geq 0$ while also ensuring that $b^T y < 0$.

This lemma essentially establishes a duality relationship between feasible solutions of linear inequalities and the existence of certain non-negative linear combinations of the constraints. It is widely used in optimization, particularly in the context of linear programming, as it helps in determining whether a system of inequalities is consistent or not. Overall, Farkas Lemma serves as a powerful tool in both theoretical and applied mathematics, especially in economics and resource allocation problems.

The Taylor expansion is a mathematical concept that allows us to approximate a function using polynomials. Specifically, it expresses a function $f(x)$ as an infinite sum of terms calculated from the values of its derivatives at a single point, typically taken to be $a$. The formula for the Taylor series is given by:

This series converges to the function $f(x)$ if the function is infinitely differentiable at the point $a$ and within a certain interval around $a$. The Taylor expansion is particularly useful in calculus and numerical analysis for approximating functions that are difficult to compute directly. Through this expansion, we can derive valuable insights into the behavior of functions near the point of expansion, making it a powerful tool in both theoretical and applied mathematics.