Neurovascular coupling refers to the relationship between neuronal activity and blood flow in the brain. When neurons become active, they require more oxygen and nutrients, which are delivered through increased blood flow to the active regions. This process is vital for maintaining proper brain function and is facilitated by the actions of various cells, including neurons, astrocytes, and endothelial cells. The signaling molecules released by active neurons, such as glutamate, stimulate astrocytes, which then promote vasodilation in nearby blood vessels, resulting in increased cerebral blood flow. This coupling mechanism ensures that regions of the brain that are more active receive adequate blood supply, thereby supporting metabolic demands and maintaining homeostasis. Understanding neurovascular coupling is crucial for insights into various neurological disorders, where this regulation may become impaired.
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