DNA methylation is a crucial epigenetic mechanism that involves the addition of a methyl group (–CH₃) to the DNA molecule, typically at the cytosine bases of CpG dinucleotides. This modification can influence gene expression without altering the underlying DNA sequence, thereby playing a vital role in gene regulation. When methylation occurs in the promoter region of a gene, it often leads to transcriptional silencing, preventing the gene from being expressed. Conversely, low levels of methylation can be associated with active gene expression.
The dynamic nature of DNA methylation is essential for various biological processes, including development, cellular differentiation, and responses to environmental factors. Additionally, abnormalities in DNA methylation patterns are linked to various diseases, including cancer, highlighting its importance in both health and disease states.
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