The Hodgkin-Huxley model is a mathematical representation that describes how action potentials in neurons are initiated and propagated. Developed by Alan Hodgkin and Andrew Huxley in the early 1950s, this model is based on experiments conducted on the giant axon of the squid. It characterizes the dynamics of ion channels and the changes in membrane potential using a set of nonlinear differential equations.
The model includes variables that represent the conductances of sodium () and potassium () ions, alongside the membrane capacitance (). The key equations can be summarized as follows:
where is the membrane potential, , , and are the reversal potentials for sodium, potassium, and leak channels, respectively. Through its detailed analysis, the Hodgkin-Huxley model revolutionized our understanding of neuronal excitability and laid the groundwork for modern neuroscience.
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