Neuron-Glia interactions are crucial for maintaining the overall health and functionality of the nervous system. Neurons, the primary signaling cells, communicate with glial cells, which serve supportive roles, through various mechanisms such as chemical signaling, electrical coupling, and extracellular matrix modulation. These interactions are vital for processes like neurotransmitter uptake, ion homeostasis, and the maintenance of the blood-brain barrier. Additionally, glial cells, especially astrocytes, play a significant role in modulating synaptic activity and plasticity, influencing learning and memory. Disruptions in these interactions can lead to various neurological disorders, highlighting their importance in both health and disease.
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